Chirality in Drug Research, Volume 33

Book Reviews: It is the 21 stereocenters in the cyclopeptide antibiotics that give always raise to a headache for my students and it takes them some time to appreciate the incredible precision of complementarity in binding of these drugs to their bacterial targets.

The fascinating world of chirality in drug research, where microorganisms have been the masters for a long time, is brought to us in this new volume in the series, edited by Eric Francotte and Wolfgang Linder. There are three major parts to reflect the chiral research and technology of today. The first one is dealing with synthesis, the second with separation and the third one with analysis and modeling.

Here the authors learn how man created a methodology to get access to a chiral universe, so far property of nature. Research started by copying biological mechanisms or simply make use of natural sources. For instance, microorganisms, have been, and are still used to produce the desired structures. Today, highly sophisticated concepts of chiral catalysis, rather a pleonasm, are able to introduce almost all desired chirality at all locations in a synthetic molecule. Proof of the concept are numerous multi-step syntheses of complex natural compounds from an immensely broad variety of sources.

Even more impressive is the development of appropriate analytics. Modern NMR technology reveals such perfect complementarity as in the case of glycopeptides at levels of atomic resolution, providing virtual threedimensional models of ligand protein interaction. Bacterial resistance and means to cope with it, can be discussed by studying models of chiral interaction in the computer.

The authors have not always been in such a lucky position. Chirality and drugs are still related to each other by the tragedy of the sedative drug thalidomide, the “wrong” enantiomer being the cause for thousands of children being born disabled. But it lasted until recently that research soothed that it would have been useless to separate the “wrong” enantiomer since the “good” one is immediately metabolized to the “bad” one in our body. The tragedy led to profound and sustainable change in the ways of thinking about individuality of molecules raising the concept of enantiomers being two different chemical entities at least with respect to drugs.

The historical perspective by Joseph Gal is therefore a perfect introductory chapter for the book. The authors would like to express our gratitude to Renate Doetzer and Frank the authorsinreich from Wiley-VCH for their invaluable support in this project.

Bibliographical Data of Chirality in Drug Research, Volume 33

Reference Type: Book
Record Number: xx
Author: Eric Francotte, Wolfgang Lindner, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Year: 2006
Place Published:
Publisher: Wiley-VCH
Number of Pages: 370
Edition: 1st
ISBN -10: 3527310762
ISBN-13: 978-3527310760
Kindle Available: ASIN: B01JXWPYLA
Buy: Get it on Amazon

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