The Kidney at a Glance

Book Reviews: The last few years have seen huge advances in our under­ standing of how the kidney works and how abnormalities of renal function can affect the whole body. These developments have often resulted from the application of molecular biology which has led to the cloning of the major transport molecules, channels and receptors in the kidney, and from careful physiologic studies of the function of these molecules in health and disease. These advances in basic science have transformed the field into one that is highly rational and understandable at all levels from molecular studies of the transporter proteins, to clinical studies of patients. As an example, although drugs such as loop diuretics have been prescribed for many years, The authors now know the precise transporter molecules, which they inhibit and The authors can now teach, study and understand their actions on patients in a completely rational manner. Unfortunately, much of this new information has remained in specialist journals in a piecemeal fashion that makes it difficult for students or physicians to access or put into context.

Our intention is to bring this science in a clear manner to all who need to understand it. The authors believe that all medical students, doctors and other health-care providers need to understand the kidney, which is the site of action of so many commonly prescribed drugs and plays a key role in the pathophysiology of so many common disorders including congestive heart failure and hypertension. The authors have written this book to draw all this new information together and integrate it with the traditional concepts of renal function and disease. The authors hope that this new approach, which integrates all the relevant disciplines, including molecular biology, physiology and clinical medicine will be of use to all whose work involves the actions of the kidney. The authors believe that this applies to all students of medicine and all physicians. The authors also hope that this book will provide the information necessary for others, such as nurses, or non-clinical scientists to rapidly familiarize themselves with the parts of the subject which they need to know.

The authors have particularly emphasized an understanding of the normal mechanisms and the pathophysiology of the renal system. Although new drugs and treatments may be developed, they must act on the same systems and the same diseases, so a knowledge of basic renal function and pathophysiology will stand the reader in good stead for many years to come. This is an exciting field and to do it justice, the authors have set up a companion website which will provide a range of supplementary information, including updates on new developments in the field. The website also contains self-­assessment material and key point summaries as well as suggestions for further reading and feedback. Do please visit the site at www.learndoctor.com.

The authors are very grateful to all at Blackwell Science for their enthusiasm and support; without them, this work would not have been possible. Lastly, the authors would like to thank our families for their support and all those who have kindly com­ mented on the manuscript, especially Dr C.G. Winearls, Dr J.D. Firth and Dr RM. Hilton. Their advice has been extremely helpful and any deficiencies that remain are entirely our own.

Bibliographical Data of The Kidney at a Glance

Reference Type: Book
Record Number: xx
Author: Chris O’Callaghan, Barry M Brenner.
Year: 2000
Place Published: Oxford Ox2 0EL, UK
Publisher: Wiley-Blackwell
Number of Pages: 120
Edition: 1st
ISBN -10: 0632052066
ISBN-13: 978-0632052066
Kindle Available: NO
Buy: Get it on Amazon

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