Pharmaceutics – Dosage Form and Design(FastTrack) 2nd ED

Book Reviews: Pharmaceutical formulation involves the rational design and manufacture of dosage forms to ensure that the required biological and physical performances of the therapeutic agent are attained. The formulation scientist is therefore expected to have knowledge of several scientific disciplines, including physical pharmaceutics, pharmaceutical chemistry and biopharmaceutics.

Pharmaceutical formulation may therefore be correctly viewed as an essential and unique component of the pharmaceutical sciences and, accordingly, the Pharmacy undergraduate degree. Due to the interdisciplinary nature, pharmaceutical formulation is often considered difficult by many students and challenging to all students. This textbook aims to ease the perceived difficulties of this subject and, hopefully, illustrate the significance of pharmaceutical formulation and the unique role of the pharmacist in the development of medicines.

The contents of this text have been designed to cover the vast majority of dosage forms that graduate pharmacists will encounter when they enter professional practice. In particular, the text aims to deliver the essential information concerning the formulation of these dosage forms in a format that will hopefully aid the understanding and hence remove the complexities of the various topics. The reader will observe that, in addition to the required theoretical aspects, each chapter contains information regarding the types (and physicochemical properties) of excipients that are used in the formulation of dosage forms. It is the author’s opinion that this information is essential to ensure that the reader is able to traverse the information gap between the theory and practice of dosage form design. In understanding the physicochemical properties of excipients (and indeed therapeutic agents), the student will be able to optimize the prepared dosage form and, in addition, will be able to answer examination questions with the appropriate depth required to attain a high grade.

Each chapter describes a category of dosage form and, whilst the exact details change, it may be observed that the format of the chapters is similar. This will assist students in understanding and recalling the required information. The formulations of liquids and suspensions for oral administration, including the required theoretical aspects, are presented in Chapters 1 and 2. In Chapters 3 and 4 the theoretical aspects and formulations of products that contain disperse phases are described. Whilst these products are mostly administered topically, the formulation of emulsions for oral administration is also described. Chapter 5 describes parenteral formulations and, in particular, illustrates strategies for the successful formulation of parenteral solutions, suspensions and emulsions (including the considerations of osmolality and sterility and methods to attain sterility).

The formulation of ocular (and related) dosage forms is described in Chapter 6. In addition to the description of ocular formulations, this chapter concisely describes the biological demands of these formulations and, in so doing, highlights the effects of formulation type on the biological performance of the preparation. Chapter 7 examines the formulation of suppositories and peccaries, describing the various formulation strategies for these dosage forms and highlighting their biological demands. The formulation of respiratory dosage forms, namely metered-dose inhalers, dry-powder inhalers and solutions for nebulization, is presented in Chapter 8. In addition to the description of the typical excipients, this chapter specifically highlights formulation factors that affect deposition of particles within the respiratory tract. It is worth noting that in Chapters 6–8 the biological aspects of drug delivery to the eye, nose, rectum, vagina and respiratory tract are described, as such information is required to ensure the design of formulations that provide optimal biological performance.

Finally, Chapters 9 and 10 describe the formulation of solid-dosage forms (tablets and capsules) with particular emphases on the excipients and methods used to prepare them, the different types of tablets and capsules, the tableting process, tableting defects and, finally, the film coating of tablets. The size of these chapters reflects the greater clinical usage of these dosage forms.

Writing this textbook presented many challenges to the author. Above all, I hope that, after completing this text, readers will gain a comprehensive understanding of pharmaceutical formulation that will enable them to formulate dosage forms and, importantly, give advice on this topic to other healthcare professionals, who are frequently unaware of the complexities of this topic.

It has been my great pleasure and privilege to have lectured on all of the topics described in this textbook to enthusiastic undergraduate and postgraduate students of pharmacy in both Northern Ireland and New Zealand. I am grateful to them, as their numerous questions and suggestions have informed the content of this textbook. I am also indebted to Professor Michael S. Roberts (University of Queensland) who, at the commencement of my academic career, inspired my enthusiasm for, and helped me navigate through, the scientific complexities of physical pharmaceutics and pharmaceutical formulation. His contribution to my career has been invaluable. My gratitude is also given to Dr. Ryan Donnelly and Dr. Gavin Andrews, both of the School of Pharmacy, Queen’s University of Belfast, for the many hours that they spent proof-reading this text and for their comments on how its content and presentation could be improved.

Finally, I am sincerely grateful for the love, encouragement and support of my mother May, my late Father Fred, my wife Linda and our children, Dray and Holly, without which this academic journey would not have been possible. This book is dedicated to them.

Bibliographical Data of Ed Pharmaceutics – Dosage Form and Design(FastTrack) 2nd ED

Reference Type: Book
Record Number: xx
Author: David Jones
Year: 2016
Place Published: London
Publisher: Pharmaceutical Press
Number of Pages: 421
Edition: 2nd
ISBN -10: 0857110780
ISBN-13: 978-0857110787
Kindle Available: NO
Buy: Get it on Amazon

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